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A decorative initial N at the beginning of the text, featuring ornate scrollwork and foliage motifs.
It should be no cause for wonder if Galen Galen of Pergamon, the prominent Roman physician and philosopher attributed more signs to the diagnosis of diseased locations than to the unnatural states themselves, for there are few ailments of the human body that do not simultaneously signify the diseased location. He himself established five signs for diseased locations, but only four for the ailments, in the first book of On Affected Parts original: "De locis affectis". The first sign of diseased locations is derived from impaired function, the second from excrements, the third from position, the fourth from the nature of the pain, and the fifth from the specific accidents. The first sign of unnatural ailments is taken from the type of excrement, the second from the nature of the location, the third from the nature of the pain, and the fourth and final from the specific accidents. All these do not apply to every single diseased location or their unnatural ailments, but only and especially to those that are proper and inseparable. For of the unhealthy signs, some are common to both the diseased parts and the ailments themselves, and some are proper. To all those signs which have been handed down to us by Galen, and especially to the specific accidents of the diseased parts and the primary and secondary sensible qualities of the ailments, we have not hesitated to add the helpful and harmful factors, according to the judgment of the skilled physicians of our time.