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Moffett, Thomas · 1578

of the passion, cough, hot catarrh, cholera morbus, and paroxysms of arthritis and kidney stones, as well as extreme wakefulness, vomiting, dysentery, and other most acute diseases which threaten the dissolution of either life or strength.
Hippocrates, Aphorisms 1, section 20. Furthermore, here we except the time of crisis artios precisely (that is, anelleipos kai autotelos without omission and complete of itself) pre-indicated, in which one must me kineein, medē neoteropoieein, mētē pharmakeiēsi, mēt’ alloisiin erethismoisin, all’ ean not move, nor introduce novelties, neither with medicines nor with other irritations, but leave it alone: as the Prince of Physicians cautiously says.
Furthermore, when a limb is to be removed because it is gangrenous, or a stone is to be removed by surgery, how excellent it would be for the sick person, having been given sleep-inducing drugs, to sleep until the end of the work: but such and such safe sleep-inducers I think, indeed, lie buried with Celsus, who often used them, and most successfully.
2. To whom. The second consideration must be sought from the state of the body, age, and disposition. For sleep-inducers cannot be administered to a full body without danger, just as they do not benefit those who are extremely emaciated. The same consideration must be held for children and the decrepit, to whom we grant anodynes applied externally rather than taken internally.
Hippocrates, Aphorisms 6, section 31. I praise, therefore, Hippocrates, who proposed for us five kinds of anodynes